Persons with 2 copies of the APOE E4 allele (4/four genotype) have a significantly higher risk of creating ADVERT than individuals with different Son goku fight Iron man shirt APOE subtypes. The APOE E2 allele, the least prevalent of the 3 common APOE alleles, is associated with the lowest threat of creating ADVERT, forty one with a lower rate of annual hippocampal atrophy and higher cerebrospinal fluid Aβ and lower phosphotau, suggesting much less ADVERT pathology. The gene encoding the ldl cholesterol – carrying apolipoprotein E (APOE) on chromosome 19 has been linked to elevated danger for AD, principally late – onset but also some early – onset cases.
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