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causing spots, dyschromia, and wrinkles. Lastly, pollutants have been associated with skin cancer . However, diet, starting from breast-feeding, is another determinant factor. Diet is the main source of antioxidants, which play a key role in our protection against air pollutants . Antioxidants are free radical scavengers and limit the interaction of free radicals in the brain . Similarly, genetic background may result in a differential susceptibility toward the oxidative stress pathway . For example, antioxidant supplementation with vitamins C and E appears to modulate the effect of ozone in asthmatic children homozygous for the GSTM1 null allele . Inflammatory cytokines released in the periphery e.g., respiratory epithelia upregulate the innate immune Toll-like receptor Such activation and the subsequent events leading to neurodegeneration have recently been observed in lung lavage in mice exposed to ambient Los Angeles particulate matter . In children, neurodevelopmental morbidities were observed after lead exposure. These children developed aggressive and delinquent behavior, reduced intelligence, learning difficulties, and hyperactivity . No level of lead exposure seems to be “safe,” and the scientific community has asked the Centers for Disease Control and Prevention to reduce the current screening guideline of 10 μgdl . Elevated amounts of lead in the environment are harmful to plants and crop growth. Neurological effects are observed in vertebrates and animals in association with high lead levels . Moreover, major sources of lead pollution in the air are metals, ore, and piston-engine aircraft. Lead poisoning is a threat to public health due to its deleterious effects upon humans, animals, and the environment, especially in the developing countries. Sulfur dioxide is a harmful gas that is emitted mainly from fossil fuel consumption or industrial activities. The annual standard for SO2 is 0 ppm . It affects human, animal, and plant life. Susceptible people as those with lung disease, old people, and children, who present a higher risk of damage. The major health problems associated with sulfur dioxide emissions in industrialized areas are respiratory irritation, bronchitis, mucus production, and bronchospasm, as it is a sensory irritant and penetrates deep into the lung converted into bisulfite and interacting with sensory receptors, causing bronchoconstriction. Moreover, skin redness, damage to the eyes and mucous membranes, and worsening of pre-existing cardiovascular disease have been observed . Air pollution can influence the quality of soil and water bodies by polluting precipitation, falling into water and soil environments . Notably, the chemistry of the soil can be amended due to acid precipitation by affecting plants, cultures, and water quality . Moreover, movement of heavy metals is favored by soil acidity, and metals are so then moving into the watery environment. It is known that heavy metals such as aluminum are noxious to wildlife

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